LHX4 antibody (AA 133-161)

Catalog No. ABIN1881496

This Rabbit Polyclonal antibody specifically detects LHX4 in WB. It exhibits reactivity toward Human and has been mentioned in 4+ publications.

Quick Overview for LHX4 antibody (AA 133-161) (ABIN1881496)

Target: LHX4 (LIM Homeobox 4 (LHX4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LHX4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB30670

Product Details anti-LHX4 Antibody

Binding Specificity: AA 133-161

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LHX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-161 amino acids from the Central region of human LHX4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-LHX4 antibody (ABIN1881496)

Castinetti, Saveanu, Reynaud, Quentien, Buffin, Brauner, Kaffel, Albarel, Guedj, El Kholy, Amin, Enjalbert, Barlier, Brue: "A novel dysfunctional LHX4 mutation with high phenotypical variability in patients with hypopituitarism." in: The Journal of clinical endocrinology and metabolism, Vol. 93, Issue 7, pp. 2790-9, (2008) (PubMed).

de Bruijn, van Dijk, Willemse, van Kessel: "The C terminus of the synovial sarcoma-associated SSX proteins interacts with the LIM homeobox protein LHX4." in: Oncogene, Vol. 27, Issue 5, pp. 653-62, (2008) (PubMed).

Pfaeffle, Hunter, Savage, Duran-Prado, Mullen, Neeb, Eiholzer, Hesse, Haddad, Stobbe, Blum, Weigel, Rhodes: "Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies." in: The Journal of clinical endocrinology and metabolism, Vol. 93, Issue 3, pp. 1062-71, (2008) (PubMed).

Liu, Luo, Liu, McNeilly, Cui: "Specificity protein 1 (Sp1) plays role in regulating LIM homeodomain transcription factor Lhx4 gene expression." in: Biochemical and biophysical research communications, Vol. 366, Issue 1, pp. 36-41, (2007) (PubMed).

Target Details for LHX4

Target: LHX4 (LIM Homeobox 4 (LHX4))

Alternative Name: LHX4

Background: This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined.

Molecular Weight: 43124

NCBI Accession: NP_203129

UniProt: Q969G2